No – if the game ran as ISO, it runs as CHD. Some very obscure homebrew may have issues, but retail games are fine.

files, emulators read CHDs directly, so you don't need to extract them before playing. How to Convert PS2 Games to CHD

Converting your library to CHD offers several game-changing advantages:

Compared to traditional ISO or BIN/CUE files, CHD offers several advantages:

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Ps2: Chd Roms [best]

No – if the game ran as ISO, it runs as CHD. Some very obscure homebrew may have issues, but retail games are fine.

files, emulators read CHDs directly, so you don't need to extract them before playing. How to Convert PS2 Games to CHD

Converting your library to CHD offers several game-changing advantages:

Compared to traditional ISO or BIN/CUE files, CHD offers several advantages: