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Design, synthesis and biological evaluation of a novel JAK‑3 inhibitor JU‑443 Journal: Journal of Medicinal Chemistry (2022) JUFE-443

JUFE‑443 (designated in the paper) is a potent, selective, orally bioavailable JAK‑3 inhibitor with promising pre‑clinical efficacy in an arthritis model. The authors propose further development toward immune‑modulatory indications (e.g., rheumatoid arthritis, graft‑versus‑host disease). Let me know how I can assist you further