Since it is portable, there is no setup wizard. However, go to Settings > Backup Scheme to set compression levels (Normal is best) and split files (Auto or 4GB for FAT32 drives).

If you work in IT support, you know the pain of arriving at a client’s broken computer only to realize you forgot to install backup software. With the portable version on a bootable USB key (or even a secondary drive), you can immediately:

The "Create Portable Version" tool is an integrated feature within the AOMEI Backupper interface.

Open the USB folder and double-click AMBooter.exe or Backupper.exe (naming varies by version). Accept the UAC prompt.