Check if your antivirus is quarantined the Securom launcher.
If you prefer to keep the original disc-checking functionality, you can force Windows to allow the SecuROM driver to load. This lowers system security. Only do this if you trust your local network and game disc. Nba 2k14 Securom Failed To Initialize
If none of the above solutions work, you can try uninstalling and reinstalling Securom: Check if your antivirus is quarantined the Securom launcher
Try running NBA 2K14 in compatibility mode: Nba 2k14 Securom Failed To Initialize