Real-time protection, especially (ransomware protection), can block .exe files from writing or reading in protected areas.
If native Settings.exe won't open:
Add exclusion for:
If none of the fixes work and you absolutely need to change resolution, controller, or graphics quality, you can manually edit the configuration file. pes 2021 settings.exe not opening
PES 2021 relies on specific Microsoft libraries to function. If Settings.exe crashes instantly without an error message, it is often because the system cannot find the required .dll files. especially (ransomware protection)