The most common cause of this error is Windows Defender (or third-party AV) quarantining the Denuvo files during a background scan. Even if you disabled the antivirus temporarily earlier, the files might still be locked away in "Virus & Threat Protection" history.
I want to be clear: This is only for legitimate owners of Metal Gear Solid V who have exhausted all other options. You have paid for the game. You own a license. Metal Gear Solid 5 Unable To Load Denuvo Library
Antivirus programs like Windows Defender frequently flag the Denuvo driver or associated DLL files as false positives, quarantining them and preventing the game from starting. The most common cause of this error is
When you press "Play" on Metal Gear Solid V , the following chain of events occurs: You have paid for the game
Background applications can hijack the Denuvo library load process.