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The film centers around Heiter, a former surgeon who has lost his medical license due to his extreme and inhumane methods. He kidnaps three tourists – Lindsay (Ashley C. Williams), Jenny (Ashlynn Yennie), and Paul (Dieter Laser) – and subjects them to a horrific surgical procedure, connecting them mouth-to-anus. Heiter's plan is to create a human centipede, a creature that will be forced to digest food through a series of connected stomachs.

The success of "The Human Centipede" led to the creation of a sequel, "The Human Centipede 2 (Full Sequence)", released in 2011. The sequel expands on the original concept, featuring a new set of victims and an even more disturbing plot. Index Of The Human Centipede