High-end gaming keyboards and mice (Logitech, Razer, Corsair) come with onboard memory macros. You can record a "cast, wait 45 seconds, reel" loop. Note: Most ToS consider this a bannable offense as well, though it is harder to detect than software bots.
While the promise of waking up to thousands of gold coins or rare crafting materials is tempting, the consequences of using the can be severe.
Avoid it.
Simpler tools, often run on PC emulators like BlueStacks, use pixel color detection to trigger clicks when the screen turns a specific color.