If settings.exe doesn’t save your changes, run it as once. On Windows 7 64-bit, permissions on Program Files (x86) can block writes to the game folder. Also uncheck “Read-only” on the entire PES 2010 directory.
To understand why you need a fixed registry file, it helps to understand the architecture of Windows. Pes 2010 Registry File For Windows 7 64 Bit Fixed
This "fixed" registry file addresses a core installation issue where Windows 7 64-bit fails to recognize the game's directory or CD key. Microsoft Learn Path Correction: It correctly maps the Wow6432Node If settings
However, if you are trying to install or run (or even modern Windows 10/11 systems), you have almost certainly run into the same, infuriating roadblock: If settings.exe doesn’t save your changes