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conn_str = ( r"DRIVER=Microsoft Access Driver (*.mdb, *.accdb);" r"DBQ=C:\Data\Inventory.accdb;" ) conn_str = urllib.parse.quote_plus(conn_str) engine = create_engine(f"access+pyodbc:///?odbc_connect=conn_str")

Because this is a Microsoft redistributable component, you must download it directly from Microsoft to avoid malware or corrupted DLL files. Download Microsoft Access Database Engine 2016 64 Bit -BEST

However, the underlying connectivity drivers must match the architecture of the application trying to access the data. conn_str = ( r"DRIVER=Microsoft Access Driver (*