Most changes apply instantly. For maximum effect, reboot your PC.
The most common argument against SSD Fresh is that modern TLC (Triple-Level Cell) and QLC (Quad-Level Cell) drives have TBW ratings so high (e.g., 600 TBW for a 1TB drive) that the average user would never hit the limit in 20 years. For a typical user writing 10GB/day, a 500GB SSD would last over 100 years.
Windows Search indexes the contents of your files so you can search for a word inside a document instantly. This constant indexing creates continuous background writes. SSD Fresh lets you limit indexing to file names only or disable it for the SSD entirely.